affliction

noun

1. a state of pain, distress, or grief; misery: They sympathized with us in our affliction.
2. a cause of mental or bodily pain, as sickness, loss, calamity, or persecution.

noun

1. a condition of great distress, pain, or suffering
2. something responsible for physical or mental suffering, such as a disease, grief, etc

n.

c.1300, from Old French afliction (11c.), from Latin afflictionem (nominative afflictio), noun of action from past participle stem of affligere (see afflict).