1. the act of amplifying or the state of being amplified.
  2. expansion of a statement, narrative, etc., as for rhetorical purposes: In the revision, the story underwent considerable amplification.
  3. a statement, narrative, etc., so expanded: The text of the second edition was an amplification.
  4. the matter or substance used to expand an idea, statement, or the like: He added an extra paragraph to his speech as an amplification.
  5. Electricity. increase in the strength of current, voltage, or power.
  6. Genetics. gene amplification.

noun Genetics.

  1. an increase in the frequency of replication of a DNA segment.
  2. such an increase induced by a polymerase chain reaction.


  1. the act or result of amplifying
  2. material added to a statement, story, etc, in order to expand or clarify it
  3. a statement, story, etc, with such additional material
  4. electronics
    1. the increase in strength of an electrical signal by means of an amplifier
    2. another word for gain 1 (def. 13)
  5. Also called: gene amplification genetics the production of multiple copies of a particular gene or DNA sequence. It can occur naturally or artificially, by genetic engineering techniques

1540s, “enlargement,” from Latin amplificationem (nominative amplificatio) “a widening, extending,” noun of action from past participle stem of amplificare (see amplify). Electronics sense is from 1915.


  1. The process of increasing the magnitude of a variable quantity, especially the magnitude of voltage, power, or current, without altering any other quality.
  2. The result of such a process.
  3. The process by which genes or DNA sequences are copied in an organism or in the laboratory.


  1. A cellular process characterized by the production of copies of a gene or genes to amplify the phenotype that the gene confers on the cell.

  1. An increase in the magnitude or strength of an electric current, a force, or another physical quantity, such as a radio signal.

  1. An increase in the number of copies of a gene in a cell, resulting in an elevation in the level of the RNA or protein encoded for by the gene and a corresponding amplification of the phenotype that the gene confers on the cell. Drug resistance in cancer cells is linked to amplification of the gene that prevents absorption of the chemotherapeutic agent by the cell.

A process in a cell by which a particular gene is replicated so that more copies are available to produce a protein for the cell’s use. For example, the genes that code for proteins involved in ribosomes are amplified early in the process of cell development so that there are sufficient numbers of them to assemble the cell.

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