verb (used with object), as·sas·si·nat·ed, as·sas·si·nat·ing.
- to kill suddenly or secretively, especially a politically prominent person; murder premeditatedly and treacherously.
- to destroy or harm treacherously and viciously: to assassinate a person’s character.
- to murder (a person, esp a public or political figure), usually by a surprise attack
- to ruin or harm (a person’s reputation, etc) by slander
1610s, from past participle stem of Medieval Latin assassinare (see ). Of reputations, characters, etc., from 1620s. Related: Assassinated; assassinating.