noun Pathology.

  1. the initial lesion of syphilis and certain other infectious diseases, commonly a more or less distinct ulcer or sore with a hard base.


  1. pathol a small hard nodular growth, which is the first diagnostic sign of acquired syphilis

also chanker, “venereal ulcer,” c.1600, from French chancre (15c.), literally “cancer,” from Latin cancer (see cancer).


  1. The primary lesion of syphilis; a hard, nonsensitive, dull red papule or area of infiltration that begins at the site of infection after an interval of 10 to 30 days.hard chancre hard ulcer

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