- the initial lesion of syphilis and certain other infectious diseases, commonly a more or less distinct ulcer or sore with a hard base.
- pathol a small hard nodular growth, which is the first diagnostic sign of acquired syphilis
also chanker, “venereal ulcer,” c.1600, from French chancre (15c.), literally “cancer,” from Latin cancer (see cancer).
- The primary lesion of syphilis; a hard, nonsensitive, dull red papule or area of infiltration that begins at the site of infection after an interval of 10 to 30 days.hard chancre hard ulcer