verb (used with object), de·plet·ed, de·plet·ing.

  1. to decrease seriously or exhaust the abundance or supply of: The fire had depleted the game in the forest. Extravagant spending soon depleted his funds.

verb (tr)

  1. to use up (supplies, money, energy, etc); reduce or exhaust
  2. to empty entirely or partially
  3. med to empty or reduce the fluid contents of (an organ or vessel)

1807, back-formation from depletion. Related: Depleted; depleting.


  1. To use up something, such as a nutrient.
  2. To empty something out, as the body of electrolytes.

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