noun Biochemistry.

  1. any of a group of enzymes that degrade DNA or RNA molecules by breaking linkages within the polynucleotide chains.


  1. an enzyme that is responsible for scission of a nucleic acid chain, the action of which is not confined to the terminal nucleotideCompare exonuclease


  1. Any of a group of enzymes that catalyze the hydrolysis of phosphodiester bonds between nucleic acids in a DNA molecule or RNA sequence.
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