reverse transcriptase

reverse transcriptase

noun Biochemistry.

  1. a retrovirus enzyme that synthesizes DNA from viral RNA, the reverse of the usual DNA-to-RNA replication: used in genetic engineering to clone genes from RNA strands.


  1. an enzyme present in retroviruses that copies RNA into DNA, thus reversing the usual flow of genetic information in which DNA is copied into RNA


  1. A polymerase that catalyzes the formation of DNA on an RNA template, found in oncogenic viruses containing RNA, especially the retroviruses.

  1. Any of a class of enzymes that catalyze the formation of DNA from an RNA template and are found in retroviruses, and also in certain body cells (such as stem cells) as the enzyme telomerase. The action of reverse transcriptase runs in the opposite direction from normal genetic transcription in the cell, in which RNA is copied from DNA. Drugs that inhibit the action of viral reverse transcriptase have been used to treat retroviral infections such as AIDS, and those that inhibit telomerase are potential anticancer agents.
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