- a combining form meaning “hard,” used with this meaning, and as a combining form of sclera, in the formation of compound words: sclerometer.
- indicating hardnesssclerosis
- of or relating to the sclerasclerotomy
before vowels scler-, word-forming element meaning “hard,” from Latinized form of Greek sklero-, comb. form of skleros “hard,” related to skellein “to dry up, parch,” from PIE *skle-ro-, from root *skele- “to parch, wither.” pref.