trichlorofluoromethane [trahy-klawr-oh-floo r-oh-meth-eyn, -flawr-; trahy-klohr-oh-floo r-oh-meth-eyn, -flohr-] Word Origin noun Chemistry. chlorotrifluoromethane. Origin of trichlorofluoromethane tri- + chloro-2 + fluoro- + methane